FLAME: A Web Tool for Functional and Literature Enrichment Analysis of Multiple Gene Lists

نویسندگان

چکیده

Functional enrichment is a widely used method for interpreting experimental results by identifying classes of proteins/genes associated with certain biological functions, pathways, diseases, or phenotypes. Despite the variety existing tools, most them can process single list per time, thus making more combinatorial analysis complicated and prone to errors. In this article, we present FLAME, web tool combining multiple lists prior analysis. Users upload several use interactive UpSet plots, as an alternative Venn diagrams, handle unions intersections among given input files. literature enrichment, along gene conversions, are offered g:Profiler aGOtool applications 197 organisms. FLAME analyze genes/proteins related articles, Gene Ontologies, annotations, regulatory motifs, domains, phenotypes, also generate protein–protein interactions derived from STRING. We have validated interrogating expression data sensitivity distal part large intestine colitis-propelled colon cancer. comes user-friendly interface easy manipulation exploration, while be visualized parameterizable heatmaps, barcharts, Manhattan networks, tables.

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ژورنال

عنوان ژورنال: Biology

سال: 2021

ISSN: ['2079-7737']

DOI: https://doi.org/10.3390/biology10070665